Prothrombin G20210A Mutation Is Associated With Young-Onset Stroke
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چکیده
منابع مشابه
The prothrombin G20210A mutation is a risk factor for sudden hearing loss in young patients.
6. Warner D, Mansfield MW, Grant PJ. Coagulation factor XIII and cardiovascular disease in UK Asian patients undergoing coronary angiography. Thromb Haemost 2001; 85: 408-11. 7. Kohler HP, Grant PJ. Clustering of haemostatic risk factors with FXIIIVal34Leu in patients with myocardial infarction. Thromb Haemost 1998; 80: 862. 8. Ariëns RAS, Kohler HP, Mansfield MW, Grant PJ. Subunit antigen and ...
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A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...
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Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
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It was the aim of the present study to investigate factor II levels in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) carrying the heterozygous G20210A prothrombin (PT) mutation. Plasma concentrations of factor II, VII, X, V, protein C (PC) total protein S (tPS) antithrombin (AT) and D-dimers (DD) were measured in 13 LC patients with PVT heterozygous for PT G20210A, in 13 LC pa...
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It has been demonstrated that inflammatory bowel disease (IBD) patients had a higher risk of thromboembolism, numerous observational studies have reported the prevalence of MTHFR C677T mutation and G20210A prothrombin mutation in patients with IBD. Whereas the magnitude of association between these two inherited thrombophilic abnormalities and IBD remains unknown. We conduct a meta-analysis to ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2014
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.113.004063